eng
Minia University
Journal of Modern Research
2636-3909
2636-3909
2019-07-01
1
1
1
7
10.21608/jmr.2019.12650.1001
41361
Antibacterial and Urease Inhibitory activity of New Piperazinyl N-4 Functionalized Ciprofloxacin-oxadiazoles
Mohamed A.A. Abdel-Aal
mohammad.abdalaal80@yahoo.com
1
Salah Abdel-Aziz
salah72aa@yahoo.com
2
Montaser Shaykoon
monoceutical@yahoo.com
3
Mamdouh Mohamed
mamdouhfawzy3@yahoo.com
4
Gamal Abuo-Rahma
gamal.aborahma@mu.edu.eg
5
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
This research includes design of new ciprofloxacin bearing oxadiazole at the N-4 piperazinyl for the purpose of having urease inhibitory activity as well as antibacterial activity. Hence, a group of new N-4 piperazinyl oxdiazole derivatives of ciprofloxacin was prepared and characterized using different spectroscopic and analytical techniques including 1H-NMR, 13C-NMR, MS and elemental analysis. Compounds 5b and 5c experienced moderate activity against the urease producing Klebsiella pneumoniae strains better than the standard drug used chloramphenicol and less than the parent drug ciprofloxacin. On the other hand, most of the tested compounds showed a urease inhibitory activity more than the parent drug, ciprofloxacin and comparable to standard, thiourea. The docked compounds exhibited better binding to urease enzyme of H. pylori than standard, AHA with binding scores for correlate to the anti-urease assay results. Compound 5b was the most potent anti-Klebsiella pneumoniae urease inhibitor with activity higher the standard (IC50 = 67.8 and 78.89 µM, respectively).
https://jmr.journals.ekb.eg/article_41361_358ab68155e6bea9aae7435aaa16fdeb.pdf
ciprofloxacin
Oxadiazole
Antibacterial
Urease inhibitors
Molecular docking
eng
Minia University
Journal of Modern Research
2636-3909
2636-3909
2019-07-01
1
1
8
12
10.21608/jmr.2019.11763.1000
41362
Exact Solutions For some nonlinear Partial Differential Equations by A Variation of (𝑮′𝑮⁄)-Expansion Method:
A. R. Shehata
shehata1433@yahoo.com
1
F. Abdel Basser
fathy776@yahoo.com
2
Safaa abu-amra
safahasoon@yahoo.com
3
Department of Mathematics, Faculty of Science, Minia University, 61519 Minia, Egypt
Department of Mathematics, Faculty of Science, Minia University, 61519 Minia, Egypt
Department of Mathematics, Faculty of Science, Minia University, 61519 Minia, Egypt|Department of Mathematics Faculty of Science, Omar Al-Mukhtar University, Al-Bayda. Libya
In this article , we study exact solutions of nonlinear of Burger’s Equation, Symmetric Regularized Long Wave (SRLW) equation, and Whitham-Broer-Kaup equations by using the variation of (G'⁄G)-expansion method, respectively. With the aid of mathematical software Maple, we can obtain the exact solutions for the above equations. Here we use the variation of (G'⁄G)-expansion method by applying it to solve the above mentioned equations, some new exact traveling wave solutions are obtained which include solitary wave solutions.When the arbitrary constants are taken some special values, the periodic and soliton solutions are obtained from the travelling wave solutions. The obtained solutions are new and not found elsewhere. It is shown that the methods are effective and can be used for many other nonlinear evolution equations (NLEEs) in mathematical physics. This methods is effectual, uncomplicated and can also be used to tackle a number of other differential equations related to mathematical physics
https://jmr.journals.ekb.eg/article_41362_1d37f54b012cc491f3792e600ce95625.pdf
The variation of (G'⁄G)-expansion method
some nonlinear partial differential equations
Exact solutions
eng
Minia University
Journal of Modern Research
2636-3909
2636-3909
2019-07-01
1
1
13
18
10.21608/jmr.2019.12713.1002
41363
Original Article
STUDYING THE INFLUENCE OF DIFFERENT COOLING TECHNIQUES ON PHOTOVOLTAIC-CELLS PERFORMANCE
Ahmed Ali
ahmali777@gmail.com
1
Khalid Abdalrahman
khharoun@gmail.com
2
S. Wahid
dr_seddik_wahid@hotmail.com
3
Department of mechanical engineering, Faculty of Engineering, Minia University, 61519 Minia, Egypt
Department of mechanical engineering, Faculty of Engineering, Minia University, 61519 Minia, Egypt
Department of mechanical engineering, Faculty of Engineering, Minia University, 61519 Minia, Egypt
The effect of temperature on the electrical parameters of photovoltaic cells is negative. The efficiency of photovoltaic cells can be enhanced by cooling which the temperature is considered as one of the main factors that affect negatively on the output power. This study was carried out to compare between three different cooling techniques and determine their effects on the output power. The first, cooling techniques is applied, the panel front surface cooled using the water spray on the surface. The second, the panel back surface cooled by extended fins. The third, the panel back surface cooled by extended fins with fans. As expected, the results of comparisons different methods using in cell cooling showed that, there is an increase in the efficiency of photovoltaic cells with the drop in cell temperature, which helps to increase the rate of photovoltaic cell performance and output power. In these experiments the output power increased 2.5%. At the first technique using water spray method the temperature dropped 7 degrees. At the other two methods the temperature dropped 3 degrees less than the panel without cooling. The used pump and fans were power consuming. So, the most effective method was cooling using the fins.
https://jmr.journals.ekb.eg/article_41363_fe498a3df16eff5fc181b8447af12429.pdf
Solar cell
Photovoltaic
heat transfer
water cooling
fins
eng
Minia University
Journal of Modern Research
2636-3909
2636-3909
2019-07-01
1
1
19
23
10.21608/jmr.2019.14281.1003
41364
Incorporating nano graphene oxide to poly-methyl methacrylate; antibacterial effect and thermal expansion.
Reem Gamal
dr.reem.gamal@mu.edu.eg
1
Yasser Gomaa
yaserfh@mu.edu.eg
2
Ashraf Said
amahrooss@yahoo.com
3
Department of Biomaterials, Faculty of Dentistry, Minia University, 61519 Minia, Egypt
Department of Biomaterials, Faculty of Dentistry, Minia University, 61519 Minia, Egypt
Department of Bio-Medical Engineering, Faculty of Engineering, Minia University, 61519 Minia, Egypt
Aim: This in vitro study was performed to evaluate antibacterial effect and thermal expansion of commercial available poly-methyl methacrylate (PMMA) incorporated by nano graphene oxide (GO) in different concentration. <br /> Method: Nano graphene oxide in five concentrations 0%, 0.05%, 0.1%, 0.15% and 1% by weight was incorporated to PMMA to form groups I-V respectively. To evaluate the antibacterial effect against Streptococcus Mutans, minimal inhibitory concentration (MIC) for GO dispersion was done and agar well diffusion test for groups I-IV was done. Thermal expansion was assessed through measuring the linear coefficient of thermal expansion.<br /> Results: For antibacterial effect, all concentrations tested for MIC showed inhibition zone varied from 0.5 to 2mm in diameter. All tested groups evaluated by agar well diffusion method showed no inhibition zones except for group II. Significant reduction in coefficient of thermal expansion was showed by increasing GO concentration.<br /> Conclusions: Incorporation of GO in to PMMA at concentration of 0.5% can inhibit the growth of Streptococcus Mutans. There is an inverse relation between the concentrations of GO and the coefficient of thermal expansion.
https://jmr.journals.ekb.eg/article_41364_adc476766946e0f7f6dbed97f0f2370b.pdf
graphene oxide
PMMA
Streptococcus mutans
MIC
Coefficient of Thermal Expansion