Cytotoxic Activities of Cymbopogon citratus Extracts Three types of human cancer cell lines were tested: Lung Carcinoma (A549), Breast Cancer (MCF-7) and Hepatocellular Carcinoma (Hep G2)

Document Type : Original Article

Authors

1 biochemistry,agriculture,minia

2 Agric. Chem. Dept., Fuc. Of Agri. Minia Univ. Egypt.

3 Central Lab of Organic Agriculture . Agri. Res. Center.

Abstract

Lemon grass is a tiny herbaceous plant in the Poaceae family known as Cymbopogon citratus. It is traditionally used to treat cancer, fever, sore throats, cough, laryngitis, bronchitis, body aches, headaches, and digestive problems, etc. The cytotoxic activity of Cymbopogon citratus Extracts Three types of human cancer cell lines were tested: Lung Carcinoma (A549), Breast Cancer (MCF-7) and Hepatocellular Carcinoma (Hep G2) are examined in this study. The plant material was chemically fractionated with ethanol 80 percent, ethyl acetate, and hexane, then tested for bioactivity. The maximum anticancer activity was found in ethyl acetate extract against A549, HepG2 , and MCF-7 human cancer cells with cell viability percentage (64.09±1.11 % , 41.22± 0.34% , and 66.24± 1.50%, respectively) with IC50 values (147, 65, and 155µg/ml, respectively). The findings demonstrate that the ethyl acetate fraction of Cymbopogon citratus is a rich source of phenolics and other chemicals that can help prevent cancer growth.

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Journal of Modern Research
Volume 4, Issue 1
January 2022
Pages 21-26

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